Notre Dame vs Ohio State Odds and Pick: Buckeyes Listed as 17-Point Favorites

Sep 2- 9 min read
Notre Dame vs Ohio State odds
  • Notre Dame heads to Ohio State as massive underdogs on Saturday, September 3rd, 2022
  • The Buckeyes are 17.0-point favorites in the Notre Dame vs Ohio State odds
  • Read below for the best Notre Dame vs Ohio State betting pick

Two national powerhouses meet in Week 1 for the first time since New Year’s Day 2016. The #5 Notre Dame Fighting Irish and first-year head coach Marcus Freeman travel to Columbus, Ohio to take on the #2 Ohio State Buckeyes. The game will take place at Ohio Stadium on Saturday, September 3rd at 7:30PM EST on ABC. The Buckeyes, to no surprise, are 17.0-point favorites in the Notre Dame vs Ohio State odds.

Marcus Freeman returns home to his alma mater to take on an extremely talented Buckeyes team. Let’s take a look at the Notre Dame vs Ohio State odds at BetMGM Sportsbook and see where we can get some value.

Notre Dame vs Ohio State Odds

Team Moneyline Spread Total
#5 Notre Dame Fighting Irish +525 +17 (-110) Over 59.5 (-110)
#2 Ohio State Buckeyes -750 -17 (-110) Under 59.5 (-110)

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Notre Dame vs Ohio State History

The Buckeyes and Irish have met only six times previously, with OSU winning the last four games. Notre Dame hasn’t defeated Ohio State since 1936, in a game they won 7-2. In the most recent meeting, Ohio State got four rushing touchdowns from Ezekiel Elliott in a 16-point win (NCAA).


2015  Ohio State 44, Notre Dame 28
2005  Ohio State 34, Notre Dame 20
1996  Ohio State 29, Notre Dame 16
1995  Ohio State 45, Notre Dame 26
1936  Notre Dame 7, Ohio State 2
1935  Notre Dame 18, Ohio State 13

Notre Dame and Ohio State are two of the most storied programs in the country. These two teams have combined for 1,873 wins all time.

  • Notre Dame are 7-1 ATS in their last 8 games.
  • Notre Dame are 5-1 SU in their last 6 games against an opponent in the Big Ten conference.
  • The total has gone OVER in 4 of Notre Dame’s last 5 games played in September.
  • Ohio State are 2-4 ATS in their last 6 games.
  • Ohio State are 7-0 SU in their last 7 games against an opponent in the Independents (FBS) conference.
  • The total has gone OVER in 5 of Ohio State’s last 5 games played in week 1.

Notre Dame Betting Outlook

Head coach Marcus Freeman took over for Brian Kelly, and there was nothing but excitement for those that stuck around the program. The Irish had an 11-2 record last season, with their two losses coming to Cincinnati and Oklahoma State. The Irish only return 59% production, with 49% returning on offense and 69% (nice) on the defensive side of the ball.

Last year the Notre Dame offense ranked 18th in points per game with 35.2 and had the 43rd most yards per play (5.9). They threw the ball a lot more effectively than they ran the ball – 4.1 yards per rush vs 8.1 yards per pass.

Defensive end Isaiah Foskey and safety Brandon Joseph are great players on the Notre Dame Defense. Foskey tied for the most forced fumbles in the country, and Joseph led the country in interceptions in 2020, but they will definitely miss safety Kyle Hamilton who left for the NFL.

Offensive coordinator Tommy Rees is one of the most conservative play callers in FBS but may need to start freshmen on the offensive line against a revamped Ohio State defense.

Ohio State Betting Outlook

The Buckeyes are one of the best offenses in the country and are littered with NFL talent. CJ Stroud is one of the best players in the country and has elite weapons in TreVeyon Henderson at half-back and Jaxon Smith-Njigba, Marvin Harrison Jr out wide. Both Stroud and JSN are contenders in the Heisman Trophy odds.

Last season, the Buckeyes led the country in points per game, yards per game, points per play, and yards per play, as well as having the third-best third down conversion percentage. It is close to impossible to keep this Buckeyes team off the field.

What led to some struggle last season if we have to nitpick was on the defensive side of the ball. The Bucks D ranked 31st in opponents points per game and 35th in yards per play. New Buckeye defensive coordinator Jim Knowles was brought in to make this one of the best units in the country.

Notre Dame vs Ohio State Pick & Prediction

I am all in on the Ohio State Buckeyes this season, and what is the worst thing they could do this Saturday? Give up points.

I believe that Ohio State and Notre Dame are going to do more than their fair share of scoring, and this total will fly over.

Take over 59.5 at -110 in the Notre Dame vs Ohio State odds at BetMGM this weekend.

Pick: Notre Dame vs Ohio State Over 59.5 (-110) 1 unit

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